The prime aim of this thesis was to investigate whether high or low iodine intake during certain periods of life was, or was not a strong risk factor for the development of canine lymphocytic thyroiditis (CLT). And secondly, if a high or low selenium intake in a combination with high or low iodine intake also may have an influence on that risk factor. To investigate this, a dietary questionnaire was sent out to dog owners. The dogs were selected from an ongoing genetic study of CLT. The questions investigated brand and type of feed during different life stages (puppy, junior and adult) and also if there were any use of dietary supplements.

Hyperthyroidism has become the most commonly diagnosed endocrine disorder in cats. The recommended treatment of choice in the literature is administration of radioactive iodine. This treatment has been available at a few veterinary clinics in Sweden since 1999. Forty-six cats treated with a standard dose (80 MBq) of radioactive iodine (131I) at the Swedish University of Agricultural Sciences in the period 2000-2004 were followed for a median of 13 months (range 3-42 months) by means of a retrospective cohort study design. Tables predicting time of survival after treatment were made. At final follow-up thirty-nine cats (85%) were euthyroid, six cats (13%) remained hyperthyroid and one cat (2%) was hypothyroid.

Sahlgrenska Academyat University of GothenburgDepartment of internal medicine and clinical nutritionAbstractTitle: Does omega-3 mitigate skin symptoms in psoriatic patients? ? A systematic review about the effects of supplementationAuthor: Anita Borgmästars and Sara LinderSupervisor: Mette AxelsenExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: May 22, 2012Background: Psoriasis is an inflammatory skin disease with high prevalency. Its treatment is time-consuming and associated with many side effects. Therefore alternative forms of treatment, among them omega-3 supplementation, have been investigated. Omega-3 is a family of polyunsaturated fatty acids whose metabolites participate in the regulation of inflammatory reactions in tissues and may therefore have a positive effect on skin symptoms in patients with psoriasis.Objective: To determine if omega-3 supplementation has a beneficial effect on skin symptoms in psoriasis compared to omega-6 supplementation by rating the evidence quality in available studies.Search strategy: The literature search was conducted in the databases PubMed, Scopus and Amed.

Sahlgrenska Academyat University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: Vitamin D supplementation and its effect on body composition in the overweightand obese ? a systematic reviewAuthor: Johanna Blum and Emma Sellin FrimodigSupervisor: Sofia KlingbergExaminer: Ingrid LarssonProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: April 10, 2013Background: There is an increasing burden of overweight and obesity worldwide. Theconditions lead to morbidity and lowered quality of life. Since there is research showing aconnection between obesity and low levels of serum 25(OH)D, this raises the question ifsupplementation of vitamin D may have positive effects on body weight, waist circumference andbody composition in the overweight and obese.Objective: To investigate if there is enough scientific evidence to recommend vitamin Dsupplementation combined with nutrition therapy to overweight and obese patients.Search strategy: The systematic collection of data was performed in the databases PubMed andScopus. Search terms included were ?vitamin D supplementation?, ?obesity? ?cohort?, ?vitamin D?,?vitamin D3 supplementation? and ?overweight?.Selection criteria: Human studies with RCT, CCT or cohort design written in English orSwedish were included.

AbstractTitle: Does supplementation with omega 3 improve oxygen uptake among athletes?Author: Jonna Gustafsson and Maria Bohlin Nygren Supervisor: Frode Slinde Examiner: Ingrid Larsson Programme: Programme in dietetics, 180/240 hp Type of paper: Bachelor?s thesis in clinical nutrition, 15 hp Date: May 26, 2015Background: Previous research has shown that omega 3 fatty acids may improve cardiovascular functions by decreased aggregation and increased red blood cell deformability. This produces an increased blood flow and could have a potential effect on oxygen uptake. Optimal aerobic capacity is a determinant factor of performance within endurance exercise.Objective: To compile scientific research of the possibility that omega 3 supplementation could improve oxygen uptake among athletes.Search strategy: The literature research is based on searches in PubMed and Scopus with the terms ?Physical Endurance?, ?Oxygen Consumption?, ?Fatty Acids Omega 3?, ?Dietary Supplements?, ?Exercise?, ?Fatty Acids Essential?, ?Docosahexaenoic Acids?, ?Eicosanoic Acids?, ?Fish Oils?, ?oxygen consumption?, ?maximal oxygen consumption?, ?VO2 max?, ?athlete?, ?omega-3 supplementation?, ?physical endurance?, ??-3?, ?omega-3?, ?Maximal Aerobic Power?, ?Oxygen Uptake?, ?VO2? and ?Maximal Aerobic Capacity?.Selection criteria: Randomized controlled trials (RCT) with an intervention of omega 3-supplementation during three weeks or more were included.

Clinicians in veterinary practice have responsibilities for the development of global antibiotic resistance. In some cases, antibiotics are contraindicated or even useless in wound treatments and therefore other options are needed. Antiseptics may be another option but their use are controversial and may be questioned by owners. As professionals, it may be very difficult to be able to motivate this choice of treatment. The aim of this paper is to gain knowledge about four antiseptics; iodine, silver, polyhexamethylene biguanide (PHMB) and honey to make it easier for veterinary nurses and other clinicians in veterinary practices to decide their potential use. The assessment will be made with consideration of the available evidence concerning the properties, usability and the animal?s experience. The results showed a lack of evidence in in-vivo studies in horses, particularly studies within the field of veterinary nursing.

The probiotic bacteria Lactobacillus reuteri DSM17938 was evaluated as a starter culture in cheese production, with the intention to produce a new interesting product within the functional food market. Growth and acidification rate in milk subjected to different heat treatments, as well as supplementation with growth promoting factors or support cultures was measured during controlled fermentations. The results showed that the weak proteolytic activity of L. reuteri could be compensated for by supplementation with 1% casamino acids or 5% MRS broth. Furthermore, a decrease in growth and acidification rate could be seen when using yoghurt culture or Lactobacillus delbrueckii as adjunct cultures.

Sahlgrenska Academyat University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: BCAA supplementation in patients undergoing resection for liver cancerAuthor: Mikael Semaan and Viktor SjölingSupervisor: Fredrik BertzExaminer: Frode SlindeProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: April 10, 2013BackgroundLiver cancer is the fifth most common cancer worldwide and the third largest to cause death. Protein-energy malnutrition is common in patients with liver disease and they often suffer from changes in the hepatic metabolism of nutrients and other substances. There is a basis for recommending BCAA supplementation in other certain liver diseases. Given the similar clinical picture of liver cancer surgery, it is possible that supplementation of BCAA can be beneficial for these patients as well.ObjectiveThe aim was to study the scientific basis for the effect of branched chain amino acid (BCAA) supplementation in liver cancer patients. Can it improve their recovery in terms of nutritional status and albumin levels, and does it changes the duration of hospital stay, after surgery?Search strategyFive extensive searches were performed on PubMed and Cochrane after appropriate study material.

The Effects of dietary biotin supplementation on hoof health in Swedish dairy cows - a controlled cohort field study. The aim of the present degree project was to investigate the effects of biotin supplementation on hoof health in dairy cows. The experiment was performed as a controlled cohort study in three commercial farms in western Sweden from January 2002 to October 2002. The cows were all housed in cubicle systems with transponder concentrate feeding systems. Within each farm the cows were allocated to either biotin or control treatment. The biotin groups received 20 mg of biotin per cow and day, starting 14 days before expected calving.

Sahlgrenska AcademyAt University of GothenburgDepartment of internal medicine and clinical nutritionAbstractTitle: D for depression: Does vitamin D supplementation have apalliative effect on depressive symptoms? ? A systematic reviewAuthor: Emelie Nacksten and Lua Ferreira RangelSupervisor: Fredrik BertzExaminer: Ingrid LarssonProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: May 22th, 2013BackgroundDepression is one of the major diseases in the world and is ranked by the WHO as the leading causeof disability. Several studies suggest that there is a correlation between low s-25(OH)D levels and theoccurrence of depression. Current research has found enzymes required for synthesis of the active formof vitamin D and its receptors (VDR) in the brain. The potential role of the vitaminas a neuroactive steroid has resulted in an increased interest in investigating the role of vitamin D in thetreatment of depression.ObjectiveStudy the scientific evidence to determine if vitamin D supplementation can relieve depressive symptomsin adults.Search strategyThe literature search was conducted in the databases Scopus, Pubmed, Cochrane and PsychInfo.

Sahlgrenska Academyat University of GothenburgDepartment of internal medicine and clinical nutritionAbstractTitle: Can supplementation with vitamin E improve cognitive function in Alzheimer?s disease?Author: Malin Andersson and Elin LöfqvistSupervisor: Elisabet RothenbergExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: 2012-04-11Background: Alzheimer?s disease (AD) is the most common form of dementia. As the average life expectancy rises the prevalence increases. The disease leads to gradual deterioration of cognitive functions. A recent Cochrane review describes how several studies demonstrate an increased oxidative damage in the brain in those with AD.

Sahlgrenska Academyat University of GothenburgDepartment of Internal Medicin and Clinical NutritionAbstractTitle: Does supplementation of omega-3 during pregnancy affectprevalence of allergy in infants and children?Author: Peter Eliasson, Anna RahmSupervisor: Lena HulthénExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 ECTSDate: 2012-04-12BackgroundEpidemiologic research has shown an association between a high intake of fish and allergy.The underlying theory is that allergy develops already at a prenatal stage and food intakeduring pregnancy has been shown to be significant. Conducting research on allergy isproblematic since it has genetic, as well as enviromental, determinants.ObjectiveThis thesis attempts to conclude and evaluate research on a connection betweensupplementation of omega-3 during pregnancy and allergic outcomes in infants and children.Search strategyThe literature search was conducted in the databases PubMed and Scopus. Among thekeywords chosen were omega 3, supplement, pregnancy and allergy.Selection criteriaHuman RCT, that measured allergy, where the intervention consisted of supplementation withomega-3 for at least ten weeks during pregnancy and ceased at birth.Data collection and analysisThree articles were chosen for this thesis. The articles were examined using templates fromSBU and the quality of evidence was evaluated according to GRADE.Main resultsNone of the articles showed a protective effect on allergic outcome but in one of the studiesthere was significant reduction in eggallergy and another showed significant lower occurrenceof severe eczema.ConclusionsSupplementation with omega-3 during pregnancy does not occur to have an protective effecton allergic outcome in infants and childen but the evidence for this is considered to bemoderate.

Sahlgrenska Academyat University of GothenburgDepartment Of Internal Medicine And Clinical NutritionAbstractTitle: The effect of CLA on body weight and body fat amongst overweight and obese.Author: Sierra De Goldsmith and Amanda EgebergSupervisor: Frode SlindeExaminer: Anna WinkvistProgram: Dietician study program 180/240 ECTSType of paper: Examination paper, 15 hpDate: April 12, 2012Background: Overweight and obesity represents a global problem as it is accompanied by an accumulation of body fat which increases the risk of developing diseases such as diabetes type 2, insulin resistance, cardio vascular diseases and certain types of cancer. Moreover, the prevalence is increasing worldwide. Many consider it difficult to reach a normal weight using only methods such as changing dietary- and exercise habits, this creating a market for products that facilitate weight loss and loss of body fat. The supplement of conjugated linoleic acid (CLA) is such a product. In animal studies, CLA has demonstrated a reduction in both body fat and weight.

Syfte: Syftet med denna systematiska ?versikt ?r att unders?ka evidensen f?r om jodtillskott under graviditet eller amning, hos personer utan allvarlig jodbrist, p?verkar barnets kognitiva utveckling. Metod: Litteraturs?kningen utf?rdes i databaserna Scopus och PubMed den 21 mars 2023. S?korden delades in i fyra block utifr?n valt PICO. Populationen var barn 0?7 ?r, interventionen var jodtillskott under graviditet eller amning, kontrollen var inget jodtillskott/placebo under graviditet eller amning, och utfallet var resultat p? kognitionstesterna Bayley-III eller WPPSI-III. Inklusionskriterierna var att studierna skulle vara RCT:er och att jodtillskotten/placebo skulle vara i tablettform.

Sahlgrenska Academyat University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: Effects of isoflavone supplementation from soybeans on LDL-cholesterol levels in adultAuthors: Malin Blomgren Alegria and Ruut ReivaaraSupervisor: Lena HulthénExaminer: Frode SlindeProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: 2013-04-08Background: One of the most common causes of death in Sweden is due to cardiovascular diseases such as heart attack and stroke. Hypercholesterolemia is one of the risk factors for cardiovascular disease. In Asia, hypercholesterolemia is less common than in the Western countries. In Asian countries, soy products are consumed in larger quantities than in the Western world, which has led to implemented research with the intention of examining soy's potential effect on cholesterol levels.Objective: To investigate whether there is scientific evidence that isoflavone supplementation from soy bean may have a lowering effect on LDL-cholesterol.Search strategy: The databases used for the systematic literature search were PubMed, Scopus and Cochrane. Keywords used were cholesterol and 9 versions of this, and isoflavones and 11 versions of that.Selection criteria: RCT articles, on humans, written in English, published from 2011 onwards, that focused on interventions with isoflavones from soybeans and its effect on blood cholesterol, the participants were over 18 years old and the study time was at least 24 weeks.